An interactive piece based on experiencing some element of living with atypical bodies to get through everyday tasks. For instance, buy a subway ticket in NYC: without vision, without being able to hear/speak, while being of small stature, while being unable to use your arms or legs, etc.
This could be accomplished with VR and the Kinect or Neuron which could then detect lack of motion etc to make sure they user was doing it properly — following the constraints.